Progress of bio-sequence modifications in Machine Learning

01.

Post-translational
modification in protein


Protein post-translational modifications including fifteen post-translational modifications, such as Phosphorylation, Acetylation, Methylation, Glycosylation, Pupylation, Palmitoylation, S-sulfenylation, and S-nitrosylation.

02.

Post-transcriptional
modification in RNA


RNA post-transcriptional modifications mainly including N6-methyladenosine, N1-methyladenosine, 5-methylcytosine, Pseudouridine, Adenosine-to-inosine (A-to-I), 2’-O-methylationation, and 5-hydroxymethylcytosine.

03.

Post-replication
modification in DNA


DNA post-replication modifications mainly including N4-methylcytosine, N6-methyladenin and 5-methylcytosine.

References:

1. Ao. et. al. Review of Progress in Predicting Protein Methylation Sites. Current Organic Chemistry. 2019, 23 (15): 1663-1670.
2. He. et. al. Research Progress in Protein Post-Translational Modification Site Prediction. Briefings in Functional Genomics. 2018, 18(4): 220-229.
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