Xiang Chen 陈祥
电子科技大学长三角研究院（衢州）
Yangtze Delta Region Institute (Quzhou)
University of Electronic Science and Technology of China
联系方式
Email：xiang-chen@zju.edu.cn
联系地址：浙江省衢州市柯城区成电路1号科创C楼210室 邮编：324003
个人简介
陈祥，电子科技大学长三角研究院（衢州）副研究员，2019年9月毕业于浙江大学药学院，获得生物信息学博士学位， 研究方向为疾病遗传信息学。已在J. Allergy Clin. Immunol., Bioinformactics, Genomics, Proteomics & Bioinformatics, Journal of Genetics and Genomics等期刊发表多篇论文。作为主要完成人获得江西省科学技术奖二等奖、参与国家科技部、国家自然科学基金和省级项目。
研究兴趣
利用生物信息学技术与机器学习，深入探索基因（不同类型基因组突变分析识别）、蛋白质（包括蛋白质相互作用、翻译后修饰及蛋白质结构）以及药物在疾病发生和治疗机制中的作用，特别是开发针对不同类型疾病的精准医疗数据库和应用。
学术工作经历
- 西湖大学医学院附属第一人民医院: 访问学者/助理研究员 (2023.05 - 2024.12)
- 浙江大学良渚实验室： 博士后/助理研究员 (2020.07 - 2023.03)
- 杭州锘崴信息技术有限公司: 生物信息科学家 (2019.10 - 2020.06)
- 杭州博圣生物科技有限公司: 生物信息工程师 (2014.07 - 2015.08)
发表论文
- Xiang Chen, Xiaomin Yu*, Towards a Universal Approach for Predicting Variant Pathogenicity in Diverse Disease Landscapes. Journal of Genetics and Genomics, 2024, doi: 10.1016/j.jgg.2024.07.015.
- Xiang Chen, Xiaomin Yu*, Cohort-driven variant burden analysis and pathogenicity identification in monogenic autoinflammatory disorders. J. Allergy Clin. Immunol., 2023, 152(2):517-527.
- Qintao Wang#, Xiang Chen#, Youyou Luo#, Taijie Jin, Yan Han, Qi Cheng, Jie Chen, Qing Zhou, Xiaomin Yu*, Gain-of-function of MEFV mutation causes very early onset inflammatory bowel disease, Journal of Clinical Immunology, 2023, 43(6):1165-1169.
- Changming Zhang, Xu Han, Ying Jin, Xiang Chen, Cheng Gong, Jiahui Peng, Yusha Wang, Xiaoxin Luo, Zhaohui Yang, Yangyang Zhang, Weiguo Wan, Xiaohui Liu, Jianhua Mao, Haiguo Yu, Jingyi Li, Li Liu, Li Sun, Sirui Yang, Yu An, Zhengzhao Liu, Erzhi Gao, Honghao Zhu, Yinghua Chen, Xiaomin Yu*, PhD, Qing Zhou*, Zhihong Liu*, Pathogenic gene spectrum and clinical implication in Chinese patients with lupus nephritis, Clin J Am Soc Nephrol, 2023, 18(7):869-880..
- Peng, Jiahui; Wang, Yusha; Han, Xu; Zhang, Changming; Chen, Xiang; Jin, Ying; Yang, Zhaohui; An, Yu; Zhang, Jiahui; Liu, Zhengzhao; Chen, Yinghua; Gao, Erzhi; Zhang, Yangyang; Xu, Feng; Zheng, Chunxia; Zhou, Qing*; Liu, Zhihong*, Clinical Implications of a New DDX58 Pathogenic Variant That Causes Lupus Nephritis due to RIG-I Hyperactivation. J. Am. Soc. Nephrol., 2023, 34(2):258-272.
- Xin Wu#, Xiang Chen#, Xiaochen Lv, and Hao Zheng*. Advances in Microbiome Detection Technologies and Application in Antirheumatic Drug Design. Curr Pharm Des., 2021;27(7):891-899.
- Xin Wu, Hao Zheng, Zuochao Dou, Feng Chen, Xiang Chen, Shuang Wang, Huji Xu et al. A Novel Privacy-Preserving Federated Genome-wide Association Study Framework and its Application in Identifying Potential Risk Variants in Ankylosing Spondylitis. Briefings in Bioinfromatics, 2021, 22(3):bbaa090.
- Xiang Chen*, Yi Guo, Xin Chen*. iGMDR: Integrated pharmacogenetic resource guide to cancer therapy and research. Genomics, Proteomics & Bioinformatics 2020, 18: 150-160. (* corresponding author)
- Xiang Chen, Xin Chen*. CancerINFO: a resource for tissue-specific accession and analysis of cancer genome features. bioRxiv 2019: 843755.
- Xiang Chen*, Yi Guo. A deep learning framework for improving protein interaction prediction using sequence properties. Database (Oxford), 2019, bioRxiv (* corresponding author)
- Yi Guo, Xiang Chen*. An integrative resource for investigating genetic model of drug response in cancer. bioRxiv 2019:555789.
- Xiang Chen, Shao-Ping Shi, Hao-Dong Xu, Sheng-Bao Suo, Jian-Ding Qiu*. A homology-based pipeline for global prediction of post-translational modification sites. Sci Rep-Uk 2016;6: 25801.
- Xiang Chen, Shao-Ping Shi, Sheng-Bao Suo, Hao-Dong Xu, Jian-Ding Qiu*. Proteomic analysis and prediction of human phosphorylation sites in subcellular level reveals subcellular specificity. Bioinformatics, 2015, 31(2): 194-200.
- Xiang Chen, Jianding Qiu*, Shaoping Shi, Shengbao Suo, Shuyun Huang, Ruping Liang. Incorporating key positions and amino acids features to identify general and species-specific ubiquitin conjugation sites. Bioinformatics, 2013, 29(13): 1614-1622.
- Xiang Chen, Jian-Ding Qiu*, Shao-Ping Shi, Sheng-Bao Suo, Ru-Ping Liang. Systematic analysis and prediction of pupylation sites in prokaryotic. PLoS ONE, 2013, 8(9): 74002.
- Shao-Ping Shi, Xiang Chen, Hao-Dong Xu, Jian-Ding Qiu*. PredHydroxy: Computational Prediction of Protein Hydroxylation Site Locations Based on the Primary Structure, Molecular BioSystems, 2015, 11: 819- 825.
- Hao-Dong Xu, Shao-Ping Shi, Xiang Chen, Jian-Ding Qiu*. Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases, Scientific Reports, 2015, 5:10900.
- Shengbao Suo, Jianding Qiu*, Shaoping Shi, Xiang Chen, Shuyun Huang, Ruping Liang. Proteome-wide analysis of amino acid variations that influences protein lysine acetylation. Journal of Proteome Research, 2013, 12 (2): 949-958.
- Sheng-Bao Suo, Jian-Ding Qiu*, Shao-Ping Shi, Xiang Chen, Ru-Ping Liang. PSEA: Kinase-specific prediction and analysis of human phosphorylation substrates. Sci Rep-Uk 2014, 4: 4524.