研究兴趣:
1. 三维基因组研究；
2. 基因转录调控研究；
3. 人工智能在生命科学中应用。
主持科研项目:
国家自然科学基金：“CTCF介导染色质环的从头预测研究”（在研）
国家自然科学基金：“基于多组学数据融合的人类基因组增强子靶基因识别”（结题）
衢州市科研项目：“人类基因组中G-四链体的识别研究”（在研）
衢州市科研项目：“整合多组学数据推断遗传疾病风险位点研究“（结题）
代表论文:
1. Li Liu*; Lu Han; Kaiyuan Han; Zheng Zhang; Haojiang Zhang; Lirong Zhang*, Identiffcation of co‐localised transcription factors based on paired motifs analysis, IET Systems Biology, 2024, https://doi.org/10.1049/syb2.12104 (IF: 1.9).
2. Li Liu*; Ranran Jia; Rui Hou; Chengbing Huang*, Prediction of cell-type-specific cohesin-mediated chromatin loops based on chromatin state, Methods, 2024, 226: 151-160 (IF: 4.2).
3. Fu-Ying Dao; Meng-Lu Liu; Wei Su; Hao Lv; Zhao-Yue Zhang; Hao Lin*; Li Liu*, AcrPred: A hybrid optimization with enumerated machine learning algorithm to predict Anti-CRISPR proteins, International Journal of Biological Macromolecules, 2023, 228: 706-714 (IF: 8.025).
4. Li Liu; Kaiyuan Han; Huimin Sun; Lu Han; Dong Gao; Qilemuge Xi; Lirong Zhang*; Hao Lin*, A comprehensive review of bioinformatics tools for chromatin loop calling, Briefings in Bioinformatics, 2023, 24(2): bbad072 (IF: 9.5).
5. Lirong Zhang; Yanchao Yang; Lu Chai; Qianzhong Li; Junjie Liu*; Hao Lin*; Li Liu*, A deep learning model to identify gene expression level using co-binding transcription factor signals, Briefings in Bioinformatics, 2022, 23(1): bbab501 (IF: 13.944).
6. Hao Lv; Fu-Ying Dao; Hasan Zulfiqar; Wei Su; Hui Ding; Li Liu*; Hao Lin*, A sequence-based deep learning approach to predict CTCF-mediated chromatin loop, Briefings in Bioinformatics, 2021, 22(5): bbab031 (IF: 11.622).
7. Fu-Ying Dao; Hao Lv; Dan Zhang; Zi-Mei Zhang; Li Liu*; Hao Lin*, DeepYY1: a deep learning approach to identigy YY1-mediated chromatin loops, Briefings in Bioinformatics, 2021, 22(4): bbaa356 (IF: 11.622).
8. Li Liu; Li-Rong Zhang*; Fu-Ying Dao; Yan-Chao Yang; Hao Lin*, A computational framework for identifying the transcription factors involved in enhancer-promoter loop formation, Molecular Therapy-Nucleic Acids, 2021, 23: 347-354 (IF: 8.886).
9. Li Liu*; Qian-Zhong Li*; Wen Jin; Hao Lv; Hao Lin*, Revealing gene function and transcription relationship by reconstructing gene-level chromatin interaction, Computational and Structural Biotechnology Journal, 2019, 17: 195-205 (IF: 7.271).
10. Li Liu; Qian-Zhong Li*; Hao Lin; Yong-Chun Zuo, The effect of regions flanking target site on siRNA potency, Genomics, 2013, 102(4): 215-222 (IF: 5.736).
