大语言模型

成员

  • 邹    权   教    授 （电子科技大学）
  • 林    琛   教    授 （同济大学）
  • 王一争   （电子科技大学）
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    项目

  • 国家自然科学基金青年基金项目：结合大语言模型和度量学习的生物序列分析研究（62502330）
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    论文

    1. Junru Jin, Yingying Yu, Ruheng Wang, Xin Zeng, Chao Pang, Yi Jiang, Zhongshen Li, Yutong Dai, Ran Su, Quan Zou, Kenta Nakai*, Leyi Wei*. iDNA-ABF: multi-scale deep biological language learning model for the interpretable prediction of DNA methylations. Genome Biology. 2022, 23: 219
    2. Jinhang Wei, Linlin Zhuo*, Xiangzheng Fu*, Xiangxiang Zeng, Li Wang, Quan Zou, Dongsheng Cao*. DrugReAlign: a multisource prompt framework for drug repurposing based on large language models. BMC Biology. 2024, 22: 226
    3. Shun Gao, Yan Xia, Xingfeng Li, Feifei Cui, Qingchen Zhang, Quan Zou, Zilong Zhang*. ACP-ESM2: Enhancing Anticancer Peptide Prediction with Pre-trained Protein Language Models. IEEE Transactions on Computational Biology and Bioinformatics. 2025, 22(3): 1041-1051
    4. Aoyun Geng, Zhenjie Luo, Aohan Li, Zilong Zhang, Quan Zou, Leyi Wei, Feifei Cui*. ACP-CLB: An anticancer peptide prediction model based on multichannel discriminative processing and integration of large pretrained protein language models. Journal of Chemical Information and Modeling. 2025, 65(5): 2336-2349
    5. Shahid Akbar, Ali Raza, Hamid Hussain Awan, Quan Zou*, Wajdi Alghamdi, Aamir Saeed. pNPs-CapsNet: Predicting Neuropeptides Using Protein Language Models and FastText Encoding-Based Weighted Multi-View Feature Integration with Deep Capsule Neural Network. ACS Omega. 2025, 10(12): 12403-12416
    6. Chaorui Yan, Zilong Zhang, Junlin Xu, Yajie Meng, Shankai Yan, Leyi Wei, Quan Zou, Qingchen Zhang, Feifei Cui*. CasPro-ESM2: Accurate identification of Cas proteins integrating pre-trained protein language model and multi-scale convolutional neural network. International Journal of Biological Macromolecules. 2025, 308: 142309
    7. Shun Gao, Yanna Jia, Feifei Cui, Junlin Xu, Yajie Meng, Leyi Wei, Qingchen Zhang, Quan Zou, Zilong Zhang. PLPTP: A Motif-Based Interpretable Deep Learning Framework Based on Protein Language Models for Peptide Toxicity Prediction. Journal of Molecular Biology. 2025, 437(12): 169115
    8. Ruiqi Liu, Shankai Yan, Zilong Zhang, Junlin Xu, Yajie Meng, Qingchen Zhang, Leyi Wei, Quan Zou, Feifei Cui*. PLM-IL4: Enhancing IL-4-inducing peptide prediction with protein language model. Computational Biology and Chemistry. 2025, 118: 108448
    9. Zitong Zhang, Quan Zou, Chunyu Wang, Junjie Wang*, Lingling Zhao*. Improving protein-protein interaction modulator predictions via knowledge-fused language models. Information Fusion. 2025, 123: 103227
    10. Shengxiang Wang, Xiangzheng Fu, Zhenya Du, Xinxin Liu*, Qiaochu Mai, Linlin Zhuo*, Boqia Xie*, Quan Zou. ViruSeg: Harnessing the Power of Large Language-Image Model for Enhanced Virus Image Segmentation. Interdisciplinary Sciences: Computational Life Sciences. 2025, 17: 987-997
    11. Shihu Jiao, Xiucai Ye*, Tetsuya Sakurai, Quan Zou, Wu Han*, Chao Zhan*. Integration of pre-trained protein language models with equivariant graph neural networks for peptide toxicity prediction. BMC Biology. 2025, 23: 229
    12. Quan Zou, Limin Jiang, Leyi Wei. Guest Editorial: Large Language Models With Applications in Bioinformatics and Biomedicine. IEEE Journal of Biomedical and Health Informatics. 2025, 29(10): 6957-6959
    13. Ziyuan Yan, Aoyun Geng, Yazi Li, Jiajing Wang, Junlin Xu, Yajie Meng, Leyi Wei, Quan Zou, Zilong Zhang, Feifei Cui*. CNNCaps-DBP: Leveraging protein language models with attention-augmented convolution for DNA-binding protein prediction. Neural Networks. 2025, 195: 108261
    14. Jinwei Wang, Zhenjie Luo, Aoyun Geng, Junlin Xu, Yajie Meng, Shankai Yan, Leyi Wei, Zilong Zhang, Qingchen Zhang, Quan Zou, Feifei Cui. DeepNhKcr: explainable deep learning framework for the prediction of crotonylation sites of non-histone lysine in plants based on pre-trained protein language model. IEEE Transactions on Computational Biology and Bioinformatics. 2026, 23(1): 326-340

      15. 最后修改时间：2026.3.23
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