Advancing microbiology with
bioinformatics and machine learning-based computational models


The microbiology group, headed by Prof. Zou, aims to improve our understanding of microbiology with bioinformatics and machine learning-based computational models.

The major scientific topics include:

  1. Microbiome in human health and diseases (oral, gut)
  2. Microbial ecology of natrual habitats (hot springs)
  3. Identify biomolecules of microorganisms (non-coding DNA, miRNAs, secreted proteins, etc.)

Group Members

Web Servers


#Co-first author, *Corresponding author.


  1. Chao Wang, Jin Wu, Lei Xu, Quan Zou*
    NonClasGP-Pred: Robust and efficient prediction of nonclassically secreted proteins by integrating subset-specific optimal models of imbalanced data
    Microbial Genomics, Nov 27 (2020).
  2. Lianwei Li, Wendy Li, Quan Zou*, Zhanshan(Sam) Ma*
    Network analysis of the hot spring microbiome sketches out possible niche differentiations among ecological guilds
    Ecological Modelling, Sep 01 (2020).
  3. Fenglong Yang, Quan Zou*
    mAML: an automated machine learning pipeline with a microbiome repository for human disease classification
    Database, June 25 (2020).
    [Web] []
  4. Chunyan Ao, Yu Zhang, Dapeng Li, Yuming Zhao*, Quan Zou*
    Progress in the development of antimicrobial peptide prediction tools. Current protein & peptide science
    Current protein & peptide scienceJan 17 (2020).

    Before 2020

  5. Kaiyang Qu, Fei Guo, Xiangrong Liu, Yuan Lin*, Quan Zou*
    Application of Machine Learning in Microbiology
    Frontiers in Microbiology10: 827 (2019).
  6. Wenying He, Ying Ju, Xiangxiang Zeng, Xiangrong Liu*, Quan Zou*
    Sc-ncDNAPred: A sequence-based predictor for identifying non-coding DNA in Saccharomyces cerevisiae
    Frontiers in Microbiology9: 2174 (2018).
    [Web Server]
  7. Hongju Chen, Shuting Peng, Lin Dai, Quan Zou*, Bin Yi, Xianghong Yang, Zhanshan (Sam) Ma
    Oral microbial community assembly under the influence of periodontitis
    PLoS One12(8):e0182259 (2017).
  8. Yong Huang, Quan Zou, Xing Jia Shen, Xue Li Yu, Zhan Bin Wang, Xiang Chao Cheng
    Construction of baculovirus expression vector of miRNAs and its expression in insect cells
    Mol Gen Mikrobiol Virusol.(2):35-9 (2012).